米兰-欧盟评估转基因黑曲霉菌株PEG生产的羧肽酶 C的安全性

欧盟评估转基因黑曲霉菌株PEG出产的羧肽酶 C的平安性时候：2024-10-17 11:14来历：食物火伴网作者： 泽夕 焦点提醒：2024年10月16日，欧盟食物平安局就一种羧肽酶 C（carboxypeptidase D）的平安性评价发布定见。 食物火伴网讯 2024年10月16日，欧盟食物平安局就一种羧肽酶 C（carboxypeptidase D）的平安性评价发布定见。 据领会，这类食物酶是由转基因黑曲霉菌株PEG出产的，旨在用在9种食物出产进程。 颠末评估，专家小组认为，在预期的利用前提下，不克不及解除饮食表露引发过敏反映的风险，特殊是对小麦过敏的人，但这类环境产生的可能性很低。按照所供给的数据，评估小组得出结论，这类食物酶在预期利用前提下不会引发平安问题。部门原文报导以下： The food enzyme carboxypeptidase C (EC 3.4.16.5) is produced with the genetically modified Aspergillus niger strain PEG by DSM Food Specialties B.V. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in nine food manufacturing processes. Dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 2.053 mg TOS/kg body weight (bw) per day in European populations. The toxicity studies were carried out with a xylanase obtained from A. niger strain XEA. The Panel considered this food enzyme as a suitable substitute for the carboxypeptidase to be used in the toxicological studies, because both strains were derived from the same recipient strain, the location of the inserts was comparable, no partial inserts were present and the production methods were essentially the same. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1850 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 901. A homology search for the amino acid sequence of the food enzyme to known allergens was made and one match with a wheat allergen was found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded, especially in wheat-allergic individuals, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. 本文由食物火伴网食物资讯中间编纂，有任何疑问，请联系news@foodmate.net。